ClearPlasma is an investigational, single-use plasma filtration device designed to remove plasminogen from human plasma. The device operates passively and is intended for use in controlled settings involving transfusion. ClearPlasma is currently undergoing evaluation in clinical trails. The device is being studied for its potential use in reducing the levels of plasminogen in specific clinical scenarios. All use to date has taken place under appropriate investigational frameworks, in accordance with local regulations and ethical approvals. For detailed information regarding investigational handling, precautions and intended use, please refer to the most recent version of the Instructions for Use (IFU) available below.