The ClearPlasma device is a non-pyrogenic, sterile, single-use device designed to remove Plasminogen and tPA from blood products, thus enabling the reduction of fibrin clot breakdown (fibrinolysis) occurring during massive bleeding. The device utilizes the chemical affinity of plasminogen to a specific ligand through its binding sites. When plasma runs through the resin bed, the plasminogen encounters the ligand that is covalently bound to the resin, and specifically binds to it. The plasma, now depleted from plasminogen, continues to flow through the device and is collected in new plasma bag ready for transfusion.