CLEARPLASMA
PLAS-FREE has developed ClearPlasma, an innovative filtration system that modifies human plasma by extracting plasminogen, an important protein responsible for dissolving blood clots.
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ClearPlasma is a disposable filter that can be used either at the patient's bedside or as part of the plasma preparation process, without affecting common clinical practices. Its safety has been proven through preclinical and clinical studies in accordance with regulatory pathways
VALUE PROPOSITION:
It is safe.
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​ClearPlasma significantly reduces the concentration of plasminogen without altering other coagulation parameters. Importantly, no thromboembolic or other adverse events were observed in human trials.
Easy to use.
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ClearPlasma can be seamlessly integrated into current plasma bag transfusion practices, causing minimal distress to patients. The filtration process does not affect transfusion time, and no additional training is required for physicians. The device can be used at the patient's bedside and/or in the blood bank.
TRANSFUSION SYSTEM
COMPETITIVE LANDSCAPE:
Available solutions: Fresh frozen plasma (FFP) is the main treatment for bleeding disorders. Although FFP is relatively cheap and safe to use, it often fails to halt bleeding due to the presence of components of fibrinolytic cascade. To address this problem, antifibrinolytic therapy using Tranexamic acid (TXA) has been used. However, these therapies have shown several main disadvantages such as their effectiveness are limited to the first 3 hours and more importantly, post and arterial thrombotic events.
rFVIIa - Recombinant activated clotting factor VII
Finally, rFVIIa is an expensive but potent procoagulant used mainly in treating haemophilia. Unlike ClearPlasma, rFVIIa does not induce the inhibition of the fibrinolytic activity. Moreover, it causes side-effects like increasing the rate of thromboembolic events in intracranial hemorrhage and cardiac surgery[i]. See the table above showing the performance of ClearPlasma vs competing solutions.
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Unique selling proposition: ClearPlasma is a cost-effective, easy-to-use filtration system that can be attached to current transfusion systems and plasma unit bags without extending the procedure's duration or requiring additional physician attention.